Folic acid in the body carries out the role of coenzyme - connecting with enzymes, it is actively involved in metabolic processes, ensuring the growth and development of the organism, including in utero. Lack of folic acid can lead to the development of severe anemia.
mechanism of action of folate
Folic acid( vitamin B9) - is a vitamin B group, which has different properties and is essential for human growth and development. In the body, folic acid is not formed, it comes with food or is synthesized in the intestine by a natural microflora. Once in the body, it forms part of the enzymes as an integral part( coenzyme) and participates in the metabolism( serine, glycine, histidine) and the synthesis of amino acids( for example, methionine) and other biologically active substances.
Folic acid is especially needed during pregnancy - it prevents the development of birth defects of the fetus. Antianemic action of folic acid is widely known - it is a stimulator of the development of red blood cells
An adult healthy person needs to receive at least 200 μg of folic acid daily, pregnant women and breastfeeding mothers two or more times more.
Folic acid is found in liver, fish, meat, cottage cheese, cheese, bakery products from wheat flour, buckwheat and oat cereals, parsley Parsley for health and beauty , lettuce, onions, cabbages of all grades, Green peas, mushrooms, strawberries. But it quickly decomposes during heat treatment.
If the diet is not sufficient folic acid, as well as the natural microflora of the intestine( dysbiosis), it can cause disruption of the ripening of erythrocytes and the development of a special type of folic deficiency anemia. In pregnant women, a deficiency of folic acid can lead to spontaneous miscarriages and to defects in the development of organs and tissues in the fetus.
After entering the stomach folic acid Folic Acid - a value is hard to overestimate connected with a special substance that plays an important role in the prevention of anemia( intrinsic factor), then absorbed in the duodenum, it falls first to the blood( binding thereWith plasma proteins), and then into the tissue, after which it partially decomposes in the liver and is excreted in the urine in the idea of metabolites and unchanged.
indications and contraindications for the use of folic acid
Folic acid is shown in the following diseases and conditions:
- for megaloblastic anemia - when very large erythrocytes with a high hemoglobin content appear in the blood, prone to destruction;
- sprue is a chronic disease typical of the tropics, which occurs with diarrhea, lesions of the mucous membrane of the gastrointestinal tract and bone marrow;
- with a decrease in the number of erythrocytes and leukocytes, which has arisen under the influence of drug treatment or increased radiation;
- in case of anemia caused by a resection of the stomach;
- in chronic gastroenteritis, which can lead to a violation of absorption of folic acid in the gastrointestinal tract;
- for intestinal tuberculosis Tuberculosis - rarely is an isolated disease - this also disrupts the absorption of folic acid;
- when pregnant and nursing a child Breastfeeding - personal choice breast - increases the need for folic acid;
- with insufficient intake of folate with food.
Folic acid in combination with individual intolerance is contraindicated. Side effects can manifest mainly in the form of allergic reactions - various kinds of itching rash, hives, Quincke's edema, bronchospasm, fever. With prolonged use of folic acid, it is necessary to periodically determine the amount of vitamin B12 in the blood.
With the simultaneous use of folic acid with certain medications( analgesic, anticonvulsant, reducing the acidity of gastric juice, sulfonamides, antibiotics, cytostatics), its effect decreases.
Folic acid is a vitamin that is vital to the human body, especially during the period of intrauterine development.